Hepatic miR-192-3p reactivation alleviates steatosis by targeting glucocorticoid receptor

Hepatic miR-192-3p reactivation alleviates steatosis by targeting glucocorticoid receptor

Background & Aims: The paradox of hepatic insulin resistance describes the inability for liver to respond to bioenergetics hormones in suppressing gluconeogenesis whilst maintaining lipid synthesis. Here, we report the deficiency of miR-192-3p in the livers of mice with diabetes and its role...

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Bibliographic Details
Main Authors: Zhangting Wang, Kai-Kei Miu, Xueyan Zhang, Angel Tsz-Yau Wan, Gang Lu, Hoi-Hung Cheung, Heung-Man Lee, Alice Pik-Shan Kong, Juliana Chung-Ngor Chan, Wai-Yee Chan
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:JHEP Reports
Subjects:
Hepatic steatosis
Diabetes mellitus
MicroRNA
Glucocorticoid receptor
Transcription repressor
High carbohydrate consumption
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555920301130

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http://www.sciencedirect.com/science/article/pii/S2589555920301130

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