Identification of Vaccinia Virus Inhibitors and Cellular Functions Necessary for Efficient Viral Replication by Screening Bioactives and FDA-Approved Drugs

Identification of Vaccinia Virus Inhibitors and Cellular Functions Necessary for Efficient Viral Replication by Screening Bioactives and FDA-Approved Drugs

Four decades after the eradication of smallpox, poxviruses continue to threaten the health of humans and other animals. Vaccinia virus (VACV) was used as the vaccine that successfully eradicated smallpox and is a prototypic member of the poxvirus family. Many cellular pathways play critical roles in...

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Bibliographic Details
Main Authors: Chen Peng, Yanan Zhou, Shuai Cao, Anil Pant, Marlene L. Campos Guerrero, Peter McDonald, Anuradha Roy, Zhilong Yang
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Vaccines
Subjects:
poxvirus
vaccinia virus
STAT3
Gaussia luciferase
high-throughput screening
small molecule inhibitor
Online Access:https://www.mdpi.com/2076-393X/8/3/401

Internet

https://www.mdpi.com/2076-393X/8/3/401

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