rs1990622 variant associates with Alzheimer’s disease and regulates TMEM106B expression in human brain tissues

Abstract Background It has been well established that the TMEM106B gene rs1990622 variant was a frontotemporal dementia (FTD) risk factor. Until recently, growing evidence highlights the role of TMEM106B in Alzheimer’s disease (AD). However, it remains largely unclear about the role of rs1990622 var...

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Bibliographic Details
Main Authors: Yang Hu, Jing-yi Sun, Yan Zhang, Haihua Zhang, Shan Gao, Tao Wang, Zhifa Han, Longcai Wang, Bao-liang Sun, Guiyou Liu
Format: Article
Language:English
Published: BMC 2021-01-01
Series:BMC Medicine
Subjects:
Online Access:https://doi.org/10.1186/s12916-020-01883-5