Prenatal Use of Sildenafil in Fetal Growth Restriction and Its Effect on Neonatal Tissue Oxygenation—A Retrospective Analysis of Hemodynamic Data From Participants of the Dutch STRIDER Trial

Prenatal Use of Sildenafil in Fetal Growth Restriction and Its Effect on Neonatal Tissue Oxygenation—A Retrospective Analysis of Hemodynamic Data From Participants of the Dutch STRIDER Trial

Objective: Sildenafil is under investigation as a potential agent to improve uteroplacental perfusion in fetal growth restriction (FGR). However, the STRIDER RCT was halted after interim analysis due to futility and higher rates of persistent pulmonary hypertension and mortality in sildenafil-expose...

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Bibliographic Details
Main Authors: Fieke Terstappen, Anne E. Richter, A. Titia Lely, Freek E. Hoebeek, Ayten Elvan-Taspinar, Arend F. Bos, Wessel Ganzevoort, Anouk Pels, Petra M. Lemmers, Elisabeth M. W. Kooi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Pediatrics
Subjects:
fetal growth restriction
Hemodynamics
near-infrared spectroscopy
regional oxygenation
sildenafil
Online Access:https://www.frontiersin.org/articles/10.3389/fped.2020.595693/full

Internet

https://www.frontiersin.org/articles/10.3389/fped.2020.595693/full

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