Deep Sequencing Reveals Novel Genetic Variants in Children with Acute Liver Failure and Tissue Evidence of Impaired Energy Metabolism.

Deep Sequencing Reveals Novel Genetic Variants in Children with Acute Liver Failure and Tissue Evidence of Impaired Energy Metabolism.

The etiology of acute liver failure (ALF) remains elusive in almost half of affected children. We hypothesized that inherited mitochondrial and fatty acid oxidation disorders were occult etiological factors in patients with idiopathic ALF and impaired energy metabolism.Twelve patients with elevated...

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Bibliographic Details
Main Authors: C Alexander Valencia, Xinjian Wang, Jin Wang, Anna Peters, Julia R Simmons, Molly C Moran, Abhinav Mathur, Ammar Husami, Yaping Qian, Rachel Sheridan, Kevin E Bove, David Witte, Taosheng Huang, Alexander G Miethke
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4970743?pdf=render

Internet

http://europepmc.org/articles/PMC4970743?pdf=render

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