Current Approaches for Glioma Gene Therapy and Virotherapy

Current Approaches for Glioma Gene Therapy and Virotherapy

Glioblastoma (GBM) is the most common and aggressive primary brain tumor in the adult population and it carries a dismal prognosis. Inefficient drug delivery across the blood brain barrier (BBB), an immunosuppressive tumor microenvironment (TME) and development of drug resistance are key barriers to...

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Bibliographic Details
Main Authors: Kaushik Banerjee, Felipe J. Núñez, Santiago Haase, Brandon L. McClellan, Syed M. Faisal, Stephen V. Carney, Jin Yu, Mahmoud S. Alghamri, Antonela S. Asad, Alejandro J. Nicola Candia, Maria Luisa Varela, Marianela Candolfi, Pedro R. Lowenstein, Maria G. Castro
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Molecular Neuroscience
Subjects:
gene therapy
glioma
viral vectors
non-viral vectors
HSV1-TK
mutant IDH1 3
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2021.621831/full

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https://www.frontiersin.org/articles/10.3389/fnmol.2021.621831/full

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