Computational approach to discriminate human and mouse sequences in patient-derived tumour xenografts

Computational approach to discriminate human and mouse sequences in patient-derived tumour xenografts

Abstract Background Patient-Derived Tumour Xenografts (PDTXs) have emerged as the pre-clinical models that best represent clinical tumour diversity and intra-tumour heterogeneity. The molecular characterization of PDTXs using High-Throughput Sequencing (HTS) is essential; however, the presence of mo...

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Bibliographic Details
Main Authors: Maurizio Callari, Ankita Sati Batra, Rajbir Nath Batra, Stephen-John Sammut, Wendy Greenwood, Harry Clifford, Colin Hercus, Suet-Feung Chin, Alejandra Bruna, Oscar M. Rueda, Carlos Caldas
Format: Article
Language:English
Published: BMC 2018-01-01
Series:BMC Genomics
Subjects:
In silico combined human-mouse reference genome
High throughput sequencing
Short-reads
Alignment
ICRG
Mouse stroma
Online Access:http://link.springer.com/article/10.1186/s12864-017-4414-y

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http://link.springer.com/article/10.1186/s12864-017-4414-y

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