Externalized Keratin 8: A Target at the Interface of Microenvironment and Intracellular Signaling in Colorectal Cancer Cells

Externalized Keratin 8: A Target at the Interface of Microenvironment and Intracellular Signaling in Colorectal Cancer Cells

Accumulating evidence supports the remarkable presence at the membrane surface of cancer cells of proteins, which are normally expressed in the intracellular compartment. Although these proteins, referred to as externalized proteins, represent a highly promising source of accessible and druggable ta...

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Bibliographic Details
Main Authors: Marie Alexandra Albaret, Claudine Vermot-Desroches, Arnaud Paré, Jean-Xavier Roca-Martinez, Lucie Malet, Jad Esseily, Laetitia Gerossier, Johan Brière, Nathalie Pion, Virginie Marcel, Frédéric Catez, Geneviève De Souza, Boris Vuillermoz, Franck Doerflinger, Emilie Lavocat, Olivier Subiger, Carine Rousset, Corinne Bresson, Elodie Mandon, Anass Jawhari, Pierre Falson, Mélissa Jasmin, Yohann Coute, Hichem-Claude Mertani, Pierre Saintigny, Jean-Jacques Diaz
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Cancers
Subjects:
<i>KRAS</i>-mutant colorectal cancer
externalized keratin 8
therapeutic target
bidirectional signaling
monoclonal antibody
Online Access:https://www.mdpi.com/2072-6694/10/11/452

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https://www.mdpi.com/2072-6694/10/11/452

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