Multi step selection in Ig H chains is initially focused on CDR3 and then on other CDR regions.

Multi step selection in Ig H chains is initially focused on CDR3 and then on other CDR regions.

Affinity maturation occurs through two selection processes: the choice of appropriate clones (clonal selection), and the internal evolution within clones, induced by somatic hyper-mutations, where high affinity mutants are selected for. When a final population of immunoglobulin sequences is observed...

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Bibliographic Details
Main Authors: Gilad eLiberman, Jennifer eBenichou, Lea eTsaban, Jacob eGlanville, Yoram eLouzoun
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-09-01
Series:Frontiers in Immunology
Subjects:
Immune System
adaptive evolution
Phylogenetic trees
micro-evolution
tree shapes
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00274/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00274/full

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