Cytochrome P450 2D6 profiles and their relationship with outcomes of primaquine anti-relapse therapy in Australian Defence Force personnel deployed to Papua New Guinea and East Timor

Cytochrome P450 2D6 profiles and their relationship with outcomes of primaquine anti-relapse therapy in Australian Defence Force personnel deployed to Papua New Guinea and East Timor

Abstract Background Primaquine, an 8-aminoquinoline with anti-hypnozoite activity against Plasmodium vivax, is metabolized by human cytochrome P450 2D6 (CYP2D6) to its active metabolite. Human CYP2D6 activities may influence the metabolism of primaquine and the risk of experiencing Plasmodium relaps...

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Bibliographic Details
Main Authors: Nanhua Chen, Simone Dowd, Michelle L. Gatton, Alyson Auliff, Michael D. Edstein, Qin Cheng
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Malaria Journal
Subjects:
Plasmodium vivax
Relapses
Primaquine
CYP2D6 allele
CYP2D6 phenotype
CYP2D6 activity score
Online Access:http://link.springer.com/article/10.1186/s12936-019-2774-2

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http://link.springer.com/article/10.1186/s12936-019-2774-2

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