RUVBL1/2 Complex Regulates Pro-Inflammatory Responses in Macrophages via Regulating Histone H3K4 Trimethylation

RUVBL1/2 Complex Regulates Pro-Inflammatory Responses in Macrophages via Regulating Histone H3K4 Trimethylation

Macrophages play an important role in the host defense mechanism. In response to infection, macrophages activate a genetic program of pro-inflammatory response to kill any invading pathogen, and initiate an adaptive immune response. We have identified RUVBL2 - an ATP-binding protein belonging to the...

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Bibliographic Details
Main Authors: Rui Zhang, Chris Y. Cheung, Sang-Uk Seo, Hang Liu, Lakhansing Pardeshi, Koon Ho Wong, Larry M. C. Chow, Mary P. Chau, Yixiang Wang, Ah Ra Lee, Woon Yong Kwon, Sheng Chen, Bill Kwan-wai Chan, Kenneth Wong, Richard K. W. Choy, Ben C. B. Ko
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
RUVBL1/2
pro-inflammatory
macrophages
epigenetic modulation
H3K4 trimethylation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.679184/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.679184/full

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