Multiple Resistance Mechanisms to Tyrosine Kinase Inhibitors in EGFR Mutated Lung Adenocarcinoma: A Case Report Harboring EGFR Mutations, MET Amplification, and Squamous Cell Transformation

Multiple Resistance Mechanisms to Tyrosine Kinase Inhibitors in EGFR Mutated Lung Adenocarcinoma: A Case Report Harboring EGFR Mutations, MET Amplification, and Squamous Cell Transformation

Resistance to EGFR tyrosin kinase inhibitors (TKI) inevitably occurs. Here it is reported the case of a young patient affected by lung adenocarcinoma harboring the L858R EGFR sensitive mutation. The patient developed multiple TKI resistance mechanisms: T790M EGFR resistance mutation, detected only o...

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Bibliographic Details
Main Authors: Rossella Bruno, Marzia Del Re, Federico Cucchiara, Iacopo Petrini, Greta Alì, Stefania Crucitta, Agnese Proietti, Simona Valleggi, Antonio Chella, Romano Danesi, Gabriella Fontanini
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Oncology
Subjects:
EGFR
lung adenocarcinoma
case report
multiple resistance mechanisms
MET amplification
squamous cell transformation
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.674604/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.674604/full

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