S100A4+ Macrophages Are Necessary for Pulmonary Fibrosis by Activating Lung Fibroblasts

S100A4+ Macrophages Are Necessary for Pulmonary Fibrosis by Activating Lung Fibroblasts

S100A4, a calcium-binding protein, can promote pulmonary fibrosis via fibroblast activation. Due partly to its various cellular origins, the exact role of S100A4 in the development of lung fibrosis remains elusive. Here, we show that in the bronchoalveolar lavage fluid, numbers of S100A4+ macrophage...

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Bibliographic Details
Main Authors: Yanan Li, Jing Bao, Yangyang Bian, Ulrike Erben, Peigang Wang, Kun Song, Shuangqing Liu, Zhenzhen Li, Zhancheng Gao, Zhihai Qin
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Immunology
Subjects:
S100A4
macrophages
fibroblasts
pulmonary fibrosis
sphingosine-1-phosphate
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01776/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01776/full

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