Fine-scale patterns of population stratification confound rare variant association tests.

Fine-scale patterns of population stratification confound rare variant association tests.

Advances in next-generation sequencing technology have enabled systematic exploration of the contribution of rare variation to Mendelian and complex diseases. Although it is well known that population stratification can generate spurious associations with common alleles, its impact on rare variant a...

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Bibliographic Details
Main Authors: Timothy D O'Connor, Adam Kiezun, Michael Bamshad, Stephen S Rich, Joshua D Smith, Emily Turner, NHLBIGO Exome Sequencing Project, ESP Population Genetics, Statistical Analysis Working Group, Suzanne M Leal, Joshua M Akey
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23861739/pdf/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23861739/pdf/?tool=EBI

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