Detection of fetal trisomy and single gene disease by massively parallel sequencing of extracellular vesicle DNA in maternal plasma: a proof-of-concept validation

Detection of fetal trisomy and single gene disease by massively parallel sequencing of extracellular vesicle DNA in maternal plasma: a proof-of-concept validation

Abstract Background During human pregnancy, placental trophectoderm cells release extracellular vesicles (EVs) into maternal circulation. Trophoblasts also give rise to cell-free DNA (cfDNA) in maternal blood, and has been used for noninvasive prenatal screening for chromosomal aneuploidy. We intend...

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Bibliographic Details
Main Authors: Weiting Zhang, Sen Lu, Dandan Pu, Haiping Zhang, Lin Yang, Peng Zeng, Fengxia Su, Zhichao Chen, Mei Guo, Ying Gu, Yanmei Luo, Huamei Hu, Yanping Lu, Fang Chen, Ya Gao
Format: Article
Language:English
Published: BMC 2019-11-01
Series:BMC Medical Genomics
Subjects:
Extracellular vesicles
evDNA
Plasma cell-free DNA
Massively parallel sequencing
Fetal trisomy
Single gene disease
Online Access:http://link.springer.com/article/10.1186/s12920-019-0590-8

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http://link.springer.com/article/10.1186/s12920-019-0590-8

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