M1 Macrophages Induce PD-L1 Expression in Hepatocellular Carcinoma Cells Through IL-1β Signaling

M1 Macrophages Induce PD-L1 Expression in Hepatocellular Carcinoma Cells Through IL-1β Signaling

Hepatocellular carcinoma (HCC) is a prototype of inflammation-related cancer, harboring M1-like and M2-like tumor-associated macrophages. M1 macrophages are thought to be tumoricidal, but some studies report its pro-tumor role. The programmed cell death-ligand (PD-L) 1 expressed in HCC cells is a cr...

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Bibliographic Details
Main Authors: Zhaoyun Zong, Jiahuan Zou, Rudi Mao, Chao Ma, Na Li, Jianing Wang, Xiaoyan Wang, Huaiyu Zhou, Lining Zhang, Yongyu Shi
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Immunology
Subjects:
hepatocellular carcinomas
PD-L1
CD274
B7-H1
macrophages
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01643/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01643/full

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