The Interplay Between Beta-Amyloid 1–42 (Aβ1–42)-Induced Hippocampal Inflammatory Response, p-tau, Vascular Pathology, and Their Synergistic Contributions to Neuronal Death and Behavioral Deficits

The Interplay Between Beta-Amyloid 1–42 (Aβ1–42)-Induced Hippocampal Inflammatory Response, p-tau, Vascular Pathology, and Their Synergistic Contributions to Neuronal Death and Behavioral Deficits

Alzheimer’s disease (AD), the most common chronic neurodegenerative disorder, has complex neuropathology. The principal neuropathological hallmarks of the disease are the deposition of extracellular β-amyloid (Aβ) plaques and neurofibrillary tangles (NFTs) comprised of hyperphosphorylated tau (p-tau...

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Bibliographic Details
Main Authors: Beatriz Calvo-Flores Guzmán, Tessa Elizabeth Chaffey, Thulani Hansika Palpagama, Sarah Waters, Jordi Boix, Warren Perry Tate, Katie Peppercorn, Michael Dragunow, Henry John Waldvogel, Richard Lewis Maxwell Faull, Andrea Kwakowsky
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Alzheiemer’s disease
β-amyloid
tau phosphorylation
cognition
neuroinflamamation
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2020.552073/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2020.552073/full

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