Variable fitness impact of HIV-1 escape mutations to cytotoxic T lymphocyte (CTL) response.

Variable fitness impact of HIV-1 escape mutations to cytotoxic T lymphocyte (CTL) response.

Human lymphocyte antigen (HLA)-restricted CD8(+) cytotoxic T lymphocytes (CTL) target and kill HIV-infected cells expressing cognate viral epitopes. This response selects for escape mutations within CTL epitopes that can diminish viral replication fitness. Here, we assess the fitness impact of escap...

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Bibliographic Details
Main Authors: Ryan M Troyer, John McNevin, Yi Liu, Shao Chong Zhang, Randall W Krizan, Awet Abraha, Denis M Tebit, Hong Zhao, Santiago Avila, Michael A Lobritz, M Juliana McElrath, Sylvie Le Gall, James I Mullins, Eric J Arts
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-04-01
Series:PLoS Pathogens
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19343217/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19343217/?tool=EBI

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