Impaired CD27+IgD+ B Cells With Altered Gene Signature in Rheumatoid Arthritis

Impaired CD27+IgD+ B Cells With Altered Gene Signature in Rheumatoid Arthritis

Natural antibodies, particularly natural IgM, are proved to play indispensable roles in the immune defenses against common infections. More recently, the protective roles of these natural IgM were also recognized in autoimmune diseases. They are mainly produced by B-1 and innate-like B cells (ILBs)....

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Bibliographic Details
Main Authors: Fanlei Hu, Wei Zhang, Lianjie Shi, Xu Liu, Yuan Jia, Liling Xu, Huaqun Zhu, Yingni Li, Dakang Xu, Liwei Lu, Xiaoyan Qiu, Wanli Liu, Junjie Qiao, Yongfu Wang, Zhanguo Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Immunology
Subjects:
rheumatoid arthritis
innate-like B cells
CD27+IgD+ B cells
natural IgM
gene signature
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00626/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00626/full

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