Genomic DNA Methylation-Derived Algorithm Enables Accurate Detection of Malignant Prostate Tissues

Genomic DNA Methylation-Derived Algorithm Enables Accurate Detection of Malignant Prostate Tissues

IntroductionThe current methodology involving diagnosis of prostate cancer (PCa) relies on the pathology examination of prostate needle biopsies, a method with high false negative rates partly due to temporospatial, molecular, and morphological heterogeneity of prostate adenocarcinoma. It is postula...

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Bibliographic Details
Main Authors: Erfan Aref-Eshghi, Laila C. Schenkel, Peter Ainsworth, Hanxin Lin, David I. Rodenhiser, Jean-Claude Cutz, Bekim Sadikovic
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Oncology
Subjects:
prostate cancer
DNA methylation
protein interaction
transcription factor binding
copy number variation
differentially methylated regions
Online Access:http://journal.frontiersin.org/article/10.3389/fonc.2018.00100/full

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http://journal.frontiersin.org/article/10.3389/fonc.2018.00100/full

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