SAR1B GTPase is necessary to protect intestinal cells from disorders of lipid homeostasis, oxidative stress, and inflammation[S]

SAR1B GTPase is necessary to protect intestinal cells from disorders of lipid homeostasis, oxidative stress, and inflammation[S]

Genetic defects in SAR1B GTPase inhibit chylomicron (CM) trafficking to the Golgi and result in a huge intraenterocyte lipid accumulation with a failure to release CMs and liposoluble vitamins into the blood circulation. The central aim of this study is to test the hypothesis that SAR1B deletion (SA...

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Bibliographic Details
Main Authors: Alain Sané, Lena Ahmarani, Edgard Delvin, Nikolas Auclair, Schohraya Spahis, Emile Levy
Format: Article
Language:English
Published: Elsevier 2019-10-01
Series:Journal of Lipid Research
Subjects:
gene silencing
SAR1 paralogues
triglyceride-rich lipoproteins
metabolism
mitochondria
intestine
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520323075

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http://www.sciencedirect.com/science/article/pii/S0022227520323075

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