Computational Investigations on the Binding Mode of Ligands for the Cannabinoid-Activated G Protein-Coupled Receptor GPR18

Computational Investigations on the Binding Mode of Ligands for the Cannabinoid-Activated G Protein-Coupled Receptor GPR18

GPR18 is an orphan G protein-coupled receptor (GPCR) expressed in cells of the immune system. It is activated by the cannabinoid receptor (CB) agonist ∆<sup>9</sup>-tetrahydrocannabinol (THC). Several further lipids have been proposed to act as GPR18 agonists, but these results still req...

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Bibliographic Details
Main Authors: Alexander Neumann, Viktor Engel, Andhika B. Mahardhika, Clara T. Schoeder, Vigneshwaran Namasivayam, Katarzyna Kieć-Kononowicz, Christa E. Müller
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Biomolecules
Subjects:
cannabinoid
docking studies
GPCR
GPR18
MD simulation
orphan GPCRs
Online Access:https://www.mdpi.com/2218-273X/10/5/686

Internet

https://www.mdpi.com/2218-273X/10/5/686

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