Proximity of Substantia Nigra Microstimulation to Putative GABAergic Neurons Predicts Modulation of Human Reinforcement Learning

Neuronal firing in the substantia nigra (SN) immediately following reward is thought to play a crucial role in human reinforcement learning. As in Ramayya et al. (2014a) we applied microstimulation in the SN of patients undergoing deep brain stimulation (DBS) for the treatment of Parkinson's di...

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Main Authors:	Ashwin G. Ramayya, Isaac Pedisich, Deborah Levy, Anastasia Lyalenko, Paul Wanda, Daniel Rizzuto, Gordon H. Baltuch, Michael J. Kahana
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2017-05-01
Series:	Frontiers in Human Neuroscience
Subjects:	substantia nigra human dopamine GABA neuron reinforcement learning
Online Access:	http://journal.frontiersin.org/article/10.3389/fnhum.2017.00200/full

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spelling	doaj-73e75e82bdd247a09f70cd5ed1d32ee02020-11-25T02:03:59ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612017-05-011110.3389/fnhum.2017.00200241131Proximity of Substantia Nigra Microstimulation to Putative GABAergic Neurons Predicts Modulation of Human Reinforcement LearningAshwin G. Ramayya0Isaac Pedisich1Deborah Levy2Anastasia Lyalenko3Paul Wanda4Daniel Rizzuto5Gordon H. Baltuch6Michael J. Kahana7Department of Neurosurgery, Perelman School of Medicine, University of PennsylvaniaPhiladelphia, PA, USADepartment of Psychology, University of PennsylvaniaPhiladelphia, PA, USADepartment of Psychology, University of PennsylvaniaPhiladelphia, PA, USADepartment of Psychology, University of PennsylvaniaPhiladelphia, PA, USADepartment of Psychology, University of PennsylvaniaPhiladelphia, PA, USADepartment of Psychology, University of PennsylvaniaPhiladelphia, PA, USADepartment of Neurosurgery, Perelman School of Medicine, University of PennsylvaniaPhiladelphia, PA, USADepartment of Psychology, University of PennsylvaniaPhiladelphia, PA, USANeuronal firing in the substantia nigra (SN) immediately following reward is thought to play a crucial role in human reinforcement learning. As in Ramayya et al. (2014a) we applied microstimulation in the SN of patients undergoing deep brain stimulation (DBS) for the treatment of Parkinson's disease as they engaged in a two-alternative reinforcement learning task. We obtained microelectrode recordings to assess the proximity of the electrode tip to putative dopaminergic and GABAergic SN neurons and applied stimulation to assess the functional importance of these neuronal populations for learning. We found that the proximity of SN microstimulation to putative GABAergic neurons predicted the degree of stimulation-related changes in learning. These results extend previous work by supporting a specific role for SN GABA firing in reinforcement learning. Stimulation near these neurons appears to dampen the reinforcing effect of rewarding stimuli.http://journal.frontiersin.org/article/10.3389/fnhum.2017.00200/fullsubstantia nigrahumandopamineGABAneuronreinforcement learning
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Ashwin G. Ramayya Isaac Pedisich Deborah Levy Anastasia Lyalenko Paul Wanda Daniel Rizzuto Gordon H. Baltuch Michael J. Kahana
spellingShingle	Ashwin G. Ramayya Isaac Pedisich Deborah Levy Anastasia Lyalenko Paul Wanda Daniel Rizzuto Gordon H. Baltuch Michael J. Kahana Proximity of Substantia Nigra Microstimulation to Putative GABAergic Neurons Predicts Modulation of Human Reinforcement Learning Frontiers in Human Neuroscience substantia nigra human dopamine GABA neuron reinforcement learning
author_facet	Ashwin G. Ramayya Isaac Pedisich Deborah Levy Anastasia Lyalenko Paul Wanda Daniel Rizzuto Gordon H. Baltuch Michael J. Kahana
author_sort	Ashwin G. Ramayya
title	Proximity of Substantia Nigra Microstimulation to Putative GABAergic Neurons Predicts Modulation of Human Reinforcement Learning
title_short	Proximity of Substantia Nigra Microstimulation to Putative GABAergic Neurons Predicts Modulation of Human Reinforcement Learning
title_full	Proximity of Substantia Nigra Microstimulation to Putative GABAergic Neurons Predicts Modulation of Human Reinforcement Learning
title_fullStr	Proximity of Substantia Nigra Microstimulation to Putative GABAergic Neurons Predicts Modulation of Human Reinforcement Learning
title_full_unstemmed	Proximity of Substantia Nigra Microstimulation to Putative GABAergic Neurons Predicts Modulation of Human Reinforcement Learning
title_sort	proximity of substantia nigra microstimulation to putative gabaergic neurons predicts modulation of human reinforcement learning
publisher	Frontiers Media S.A.
series	Frontiers in Human Neuroscience
issn	1662-5161
publishDate	2017-05-01
description	Neuronal firing in the substantia nigra (SN) immediately following reward is thought to play a crucial role in human reinforcement learning. As in Ramayya et al. (2014a) we applied microstimulation in the SN of patients undergoing deep brain stimulation (DBS) for the treatment of Parkinson's disease as they engaged in a two-alternative reinforcement learning task. We obtained microelectrode recordings to assess the proximity of the electrode tip to putative dopaminergic and GABAergic SN neurons and applied stimulation to assess the functional importance of these neuronal populations for learning. We found that the proximity of SN microstimulation to putative GABAergic neurons predicted the degree of stimulation-related changes in learning. These results extend previous work by supporting a specific role for SN GABA firing in reinforcement learning. Stimulation near these neurons appears to dampen the reinforcing effect of rewarding stimuli.
topic	substantia nigra human dopamine GABA neuron reinforcement learning
url	http://journal.frontiersin.org/article/10.3389/fnhum.2017.00200/full
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Proximity of Substantia Nigra Microstimulation to Putative GABAergic Neurons Predicts Modulation of Human Reinforcement Learning

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