Expression level, cellular compartment and metabolic network position all influence the average selective constraint on mammalian enzymes
<p>Abstract</p> <p>Background</p> <p>A gene's position in regulatory, protein interaction or metabolic networks can be predictive of the strength of purifying selection acting on it, but these relationships are neither universal nor invariably strong. Following wor...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2011-04-01
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| Series: | BMC Evolutionary Biology |
| Online Access: | http://www.biomedcentral.com/1471-2148/11/89 |