Contribution of Common Genetic Variants to Familial Aggregation of Disease and Implications for Sequencing Studies.

Contribution of Common Genetic Variants to Familial Aggregation of Disease and Implications for Sequencing Studies.

Despite genetics being accepted as the primary cause of familial aggregation for most diseases, it is still unclear whether afflicted families are likely to share a single highly penetrant rare variant, many minimally penetrant common variants, or a combination of the two types of variants. We there...

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Main Authors: Andrew Schlafly, Ruth M Pfeiffer, Eduardo Nagore, Susana Puig, Donato Calista, Paola Ghiorzo, Chiara Menin, Maria Concetta Fargnoli, Ketty Peris, Lei Song, Tongwu Zhang, Jianxin Shi, Maria Teresa Landi, Joshua Neil Sampson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-11-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1008490

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https://doi.org/10.1371/journal.pgen.1008490

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