New Multiscale Characterization Methodology for Effective Determination of Isolation–Structure–Function Relationship of Extracellular Vesicles

New Multiscale Characterization Methodology for Effective Determination of Isolation–Structure–Function Relationship of Extracellular Vesicles

Extracellular vesicles (EVs) have been lauded as next-generation medicines, but very few EV-based therapeutics have progressed to clinical use. Limited clinical translation is largely due to technical barriers that hamper our ability to mass produce EVs, i.e., to isolate, purify, and characterize th...

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Bibliographic Details
Main Authors: Thanh Huyen Phan, Shiva Kamini Divakarla, Jia Hao Yeo, Qingyu Lei, Priyanka Tharkar, Taisa Nogueira Pansani, Kathryn G. Leslie, Maggie Tong, Victoria A. Coleman, Åsa Jämting, Mar-Dean Du Plessis, Elizabeth J. New, Bill Kalionis, Philip Demokritou, Hyun-Kyung Woo, Yoon-Kyoung Cho, Wojciech Chrzanowski
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
extracellular vesicles
mesenchymal stromal/stem cell
isolation methods
ultracentrifugation
tangential flow filtration
nanodosimetry
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2021.669537/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2021.669537/full

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