PDGF upregulates Mcl-1 through activation of β-catenin and HIF-1α-dependent signaling in human prostate cancer cells.

PDGF upregulates Mcl-1 through activation of β-catenin and HIF-1α-dependent signaling in human prostate cancer cells.

Aberrant platelet derived growth factor (PDGF) signaling has been associated with prostate cancer (PCa) progression. However, its role in the regulation of PCa cell growth and survival has not been well characterized.Using experimental models that closely mimic clinical pathophysiology of PCa progre...

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Bibliographic Details
Main Authors: Shareen Iqbal, Shumin Zhang, Adel Driss, Zhi-Ren Liu, Hyeong-Reh Choi Kim, Yanru Wang, Chad Ritenour, Haiyen E Zhau, Omer Kucuk, Leland W K Chung, Daqing Wu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3262835?pdf=render

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http://europepmc.org/articles/PMC3262835?pdf=render

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