IL4/STAT6 Signaling Activates Neural Stem Cell Proliferation and Neurogenesis upon Amyloid-β42 Aggregation in Adult Zebrafish Brain

IL4/STAT6 Signaling Activates Neural Stem Cell Proliferation and Neurogenesis upon Amyloid-β42 Aggregation in Adult Zebrafish Brain

Human brains are prone to neurodegeneration, given that endogenous neural stem/progenitor cells (NSPCs) fail to support neurogenesis. To investigate the molecular programs potentially mediating neurodegeneration-induced NSPC plasticity in regenerating organisms, we generated an Amyloid-β42 (Aβ42)-de...

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Bibliographic Details
Main Authors: Prabesh Bhattarai, Alvin Kuriakose Thomas, Mehmet Ilyas Cosacak, Christos Papadimitriou, Violeta Mashkaryan, Cynthia Froc, Susanne Reinhardt, Thomas Kurth, Andreas Dahl, Yixin Zhang, Caghan Kizil
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Cell Reports
Subjects:
zebrafish
neurodegeneration
Amyloid-β42
interlukin-4
STAT6
neural stem cell
regeneration
Alzheimer’s disease
inflammation
neuro-immune crosstalk
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716313316

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http://www.sciencedirect.com/science/article/pii/S2211124716313316

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