Stereotactic cisternal lavage in patients with aneurysmal subarachnoid hemorrhage with urokinase and nimodipine for the prevention of secondary brain injury (SPLASH): study protocol for a randomized controlled trial

Stereotactic cisternal lavage in patients with aneurysmal subarachnoid hemorrhage with urokinase and nimodipine for the prevention of secondary brain injury (SPLASH): study protocol for a randomized controlled trial

Abstract Background Delayed cerebral infarction (DCI) is a major cause of death and poor neurological outcome in patients with aneurysmal subarachnoid hemorrhage (aSAH). Direct intrathecal therapies with fibrinolytic and spasmolytic drugs have appeared promising in clinical trials. However, access t...

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Bibliographic Details
Main Authors: Roland Roelz, Fabian Schubach, Volker A. Coenen, Carolin Jenkner, Christian Scheiwe, Jürgen Grauvogel, Wolf-Dirk Niesen, Horst Urbach, Christian Taschner, Jochen Seufert, Jürgen Kätzler, Jürgen Beck, Peter C. Reinacher
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Trials
Subjects:
Delayed cerebral infarction (DCI)
Aneurysmal subarachnoid hemorrhage (aSAH)
Clinical trial
Stereotactic ventriculocisternostomy (STX-VCS)
Urokinase
Nimodipine
Online Access:https://doi.org/10.1186/s13063-021-05208-6

Internet

https://doi.org/10.1186/s13063-021-05208-6

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