Distinct Immunomodulatory Effects of Spermine Oxidase in Colitis Induced by Epithelial Injury or Infection

Distinct Immunomodulatory Effects of Spermine Oxidase in Colitis Induced by Epithelial Injury or Infection

Polyamines have been implicated in numerous biological processes, including inflammation and carcinogenesis. Homeostatic regulation leads to interconversion of the polyamines putrescine and the downstream metabolites spermidine and spermine. The enzyme spermine oxidase (SMOX), which back-converts sp...

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Bibliographic Details
Main Authors: Alain P. Gobert, Nicole T. Al-Greene, Kshipra Singh, Lori A. Coburn, Johanna C. Sierra, Thomas G. Verriere, Paula B. Luis, Claus Schneider, Mohammad Asim, Margaret M. Allaman, Daniel P. Barry, John L. Cleveland, Christina E. Destefano Shields, Robert A. Casero, M. Kay Washington, M. Blanca Piazuelo, Keith T. Wilson
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Immunology
Subjects:
colitis
infection
polyamines
spermidine
spermine oxidase
mucosal immune response
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01242/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.01242/full

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