Mechanisms of BK Channel Activation by Docosahexaenoic Acid in Rat Coronary Arterial Smooth Muscle Cells

Mechanisms of BK Channel Activation by Docosahexaenoic Acid in Rat Coronary Arterial Smooth Muscle Cells

Aim: Docosahexaenoic acid (DHA) is known to activate the vascular large-conductance calcium-activated potassium (BK) channels and has protective effects on the cardiovascular system. However, the underlying mechanisms through which DHA activates BK channels remain unclear. In this study, we determin...

Full description

Bibliographic Details
Main Authors: Ling-Ling Qian, Man-Qing Sun, Ru-Xing Wang, Tong Lu, Ying Wu, Shi-Peng Dang, Xu Tang, Yuan Ji, Xiao-Yu Liu, Xiao-Xi Zhao, Wen Wang, Qiang Chai, Min Pan, Fu Yi, Dai-Min Zhang, Hon-Chi Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Pharmacology
Subjects:
docosahexaenoic acid
BK channel
cytosolic calcium
PLC–IP3 signal pathway
coronary arterial smooth muscle cells
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00223/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00223/full

Similar Items