Mediobasal hypothalamic overexpression of DEPTOR protects against high-fat diet-induced obesity

Background/Objective: The mechanistic target of rapamycin (mTOR) is a serine–threonine kinase that functions into distinct protein complexes (mTORC1 and mTORC2) that regulate energy homeostasis. DEP-domain containing mTOR-interacting protein (DEPTOR) is part of these complexes and is known to dampen...

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Bibliographic Details
Main Authors: Alexandre Caron, Sébastien M. Labbé, Damien Lanfray, Pierre-Gilles Blanchard, Romain Villot, Christian Roy, David M. Sabatini, Denis Richard, Mathieu Laplante
Format: Article
Language:English
Published: Elsevier 2016-02-01
Series:Molecular Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877815002173