Efficient identification of neoantigen-specific T-cell responses in advanced human ovarian cancer
Abstract Background Efficient identification of neoantigen-specific T-cell responses in epithelial ovarian cancer (EOC) remains a challenge. Existing investigations of spontaneous T-cell response to tumor neoepitope in EOC have taken the approach of comprehensive screening all neoantigen candidates,...
Main Authors: | Song Liu, Junko Matsuzaki, Lei Wei, Takemasa Tsuji, Sebastiano Battaglia, Qiang Hu, Eduardo Cortes, Laiping Wong, Li Yan, Mark Long, Anthony Miliotto, Nicholas W. Bateman, Shashikant B. Lele, Thinle Chodon, Richard C. Koya, Song Yao, Qianqian Zhu, Thomas P. Conrads, Jianmin Wang, George L. Maxwell, Amit A. Lugade, Kunle Odunsi |
---|---|
Format: | Article |
Language: | English |
Published: |
BMJ Publishing Group
2019-06-01
|
Series: | Journal for ImmunoTherapy of Cancer |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s40425-019-0629-6 |
Similar Items
-
A rare population of tumor antigen-specific CD4+CD8+ double-positive αβ T lymphocytes uniquely provide CD8-independent TCR genes for engineering therapeutic T cells
by: Junko Matsuzaki, et al.
Published: (2019-01-01) -
The JAK2V617F and CALR exon 9 mutations are shared immunogenic neoantigens in hematological malignancy
by: Morten Orebo Holmström, et al.
Published: (2017-11-01) -
Neoantigens retention in patient derived xenograft models mediates autologous T cells activation in ovarian cancer
by: Muzamil Yaqub Want, et al.
Published: (2019-06-01) -
Characterization of CD8+ T-cell responses to non-anchor-type HLA class I neoantigens with single amino-acid substitutions
by: Tomoyo Shinkawa, et al.
Published: (2021-01-01) -
A liposomal RNA vaccine inducing neoantigen-specific CD4+ T cells augments the antitumor activity of local radiotherapy in mice
by: Nadja Salomon, et al.
Published: (2020-01-01)