TGFβ signaling limits lineage plasticity in prostate cancer.
Although treatment options for localized prostate cancer (CaP) are initially effective, the five-year survival for metastatic CaP is below 30%. Mutation or deletion of the PTEN tumor suppressor is a frequent event in metastatic CaP, and inactivation of the transforming growth factor (TGF) ß signalin...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2018-05-01
|
Series: | PLoS Genetics |
Online Access: | http://europepmc.org/articles/PMC5983872?pdf=render |