High glucose and low specific cell growth but not mild hypothermia improve specific r-protein productivity in chemostat culture of CHO cells.

High glucose and low specific cell growth but not mild hypothermia improve specific r-protein productivity in chemostat culture of CHO cells.

In the biopharmaceutical sector, Chinese hamster ovary (CHO) cells have become the host of choice to produce recombinant proteins (r-proteins) due to their capacity for correct protein folding, assembly, and posttranslational modification. However, the production of therapeutic r-proteins in CHO cel...

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Bibliographic Details
Main Authors: Mauricio Vergara, Mauro Torres, Andrea Müller, Verónica Avello, Cristian Acevedo, Julio Berrios, Juan G Reyes, Norma A Valdez-Cruz, Claudia Altamirano
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6095543?pdf=render

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http://europepmc.org/articles/PMC6095543?pdf=render

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