Synergistic antiproliferative effects of an mTOR inhibitor (rad001) plus gemcitabine on cholangiocarcinoma by decreasing choline kinase activity

Synergistic antiproliferative effects of an mTOR inhibitor (rad001) plus gemcitabine on cholangiocarcinoma by decreasing choline kinase activity

Although gemcitabine plus cisplatin is the gold standard chemotherapy regimen for advanced cholangiocarcinoma, the response rate has been disappointing. This study aims to investigate a novel therapeutic regimen [gemcitabine plus everolimus (rad001), an mTOR inhibitor] for cholangiocarcinoma. Gemcit...

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Bibliographic Details
Main Authors: Gigin Lin, Kun-Ju Lin, Frank Wang, Tse-Ching Chen, Tzu-Chen Yen, Ta-Sen Yeh
Format: Article
Language:English
Published: The Company of Biologists 2018-08-01
Series:Disease Models & Mechanisms
Subjects:
Cholangiocarcinoma
Choline kinase
FAS
Gemcitabine
Rad001
Online Access:http://dmm.biologists.org/content/11/8/dmm033050

Internet

http://dmm.biologists.org/content/11/8/dmm033050

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