The Role of Apolipoprotein E (APOE) Genotype in Early Mild Cognitive Impairment (E-MCI)

The Role of Apolipoprotein E (APOE) Genotype in Early Mild Cognitive Impairment (E-MCI)

Objective: Our goal was to evaluate the association APOE with amyloid deposition, cerebrospinal fluid levels (CSF) of Aβ, tau, and p-tau, brain atrophy, cognition and cognitive complaints in E-MCI patients and cognitively healthy older adults (HC) in the ADNI-2 cohort. Methods: 209 E-MCI and 123 HC...

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Bibliographic Details
Main Authors: Shannon L Risacher, Sungeun eKim, Li eShen, Kwangsik eNho, Tatiana eForoud, Robert C Green, Ronald C Petersen, Clifford R Jack, Paul S Aisen, Robert A Koeppe, William J Jagust, Leslie M Shaw, John Q Trojanowski, Michael W Weiner, Andrew J Saykin
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-04-01
Series:Frontiers in Aging Neuroscience
Subjects:
positron emission tomography (PET)
Apolipoprotein E (APOE)
early mild cognitive impairment (E-MCI)
Florbetapir/AV-45/Amyvid
magnetic resonance imaging (MRI)
cerebrospinal fluid (CSF)
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2013.00011/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnagi.2013.00011/full

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