Junctophilins: Key Membrane Tethers in Muscles and Neurons

Junctophilins: Key Membrane Tethers in Muscles and Neurons

Contacts between the endoplasmic reticulum (ER) and plasma membrane (PM) contain specialized tethering proteins that bind both ER and PM membranes. In excitable cells, ER–PM contacts play an important role in calcium signaling and transferring lipids. Junctophilins are a conserved family of ER–PM te...

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Bibliographic Details
Main Authors: Christopher A. Piggott, Yishi Jin
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
membrane contact site proteins
ER–PM tethers
calcium channels
RyR channels
jph-1
synaptic transmission
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2021.709390/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2021.709390/full

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