Immunostimulatory Defective Viral Genomes from Respiratory Syncytial Virus Promote a Strong Innate Antiviral Response during Infection in Mice and Humans.

Immunostimulatory Defective Viral Genomes from Respiratory Syncytial Virus Promote a Strong Innate Antiviral Response during Infection in Mice and Humans.

Human respiratory syncytial virus (RSV) is a major cause of severe respiratory illness in children and susceptible adults. RSV blocks the development of the innate antiviral immune response and can grow to high titers in the respiratory tract. Here we demonstrate that immunostimulatory defective vir...

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Bibliographic Details
Main Authors: Yan Sun, Deepika Jain, Cynthia J Koziol-White, Emmanuelle Genoyer, Micah Gilbert, Karla Tapia, Reynold A Panettieri, Richard L Hodinka, Carolina B López
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-09-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4559413?pdf=render

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http://europepmc.org/articles/PMC4559413?pdf=render

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