Gcn5-Related N-Acetyltransferases (GNATs) With a Catalytic Serine Residue Can Play Ping-Pong Too

Gcn5-Related N-Acetyltransferases (GNATs) With a Catalytic Serine Residue Can Play Ping-Pong Too

Enzymes in the Gcn5-related N-acetyltransferase (GNAT) superfamily are widespread and critically involved in multiple cellular processes ranging from antibiotic resistance to histone modification. While acetyl transfer is the most widely catalyzed reaction, recent studies have revealed that these en...

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Bibliographic Details
Main Authors: Jackson T. Baumgartner, Thahani S. Habeeb Mohammad, Mateusz P. Czub, Karolina A. Majorek, Xhulio Arolli, Cillian Variot, Madison Anonick, Wladek Minor, Miguel A. Ballicora, Daniel P. Becker, Misty L. Kuhn
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Molecular Biosciences
Subjects:
Gcn5-related N-acetyltransferase
ping-pong kinetic mechanism
acetylation
acetyltransferase
docking
enzyme mechanism
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.646046/full

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https://www.frontiersin.org/articles/10.3389/fmolb.2021.646046/full

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