Mechanistic evaluation and transcriptional signature of a glutathione S-transferase omega 1 inhibitor

Mechanistic evaluation and transcriptional signature of a glutathione S-transferase omega 1 inhibitor

Glutathione S-transferase omega 1 (GSTO1) is an atypical GST isoform overexpressed in several cancers that has been implicated in drug resistance. Here the authors identify a small molecule inhibitor of GSTO1 that effectively inhibits tumor growth in colon cancer models, and establish its mechanism...

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Bibliographic Details
Main Authors: Kavya Ramkumar, Soma Samanta, Anahita Kyani, Suhui Yang, Shuzo Tamura, Elizabeth Ziemke, Jeanne A. Stuckey, Si Li, Krishnapriya Chinnaswamy, Hiroyuki Otake, Bikash Debnath, Vladimir Yarovenko, Judith S. Sebolt-Leopold, Mats Ljungman, Nouri Neamati
Format: Article
Language:English
Published: Nature Publishing Group 2016-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms13084

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https://doi.org/10.1038/ncomms13084

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