Central and Peripheral Mechanisms in ApoE4-Driven Diabetic Pathology

Central and Peripheral Mechanisms in ApoE4-Driven Diabetic Pathology

Apolipoprotein E (<i>APOE</i>) &#949;4 gene allele and type 2 diabetes mellitus (T2DM) are prime risk factors for Alzheimer&#8217;s disease (AD). Despite evidence linking T2DM and apoE4, the mechanism underlying their interaction is yet to be determined. In the present study, we...

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Bibliographic Details
Main Authors: Amit Koren-Iton, Shiran Salomon-Zimri, Alex Smolar, Efrat Shavit-Stein, Amir Dori, Joab Chapman, Daniel M. Michaelson
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:International Journal of Molecular Sciences
Subjects:
alzheimer’s disease (ad)
apolipoprotein e4 (apoe4)
type 2 diabetes mellitus (t2dm)
targeted replacement (tr) mice
high-fat diet (hfd)
hippocampus
insulin signaling
insulin resistance
Online Access:https://www.mdpi.com/1422-0067/21/4/1289

Internet

https://www.mdpi.com/1422-0067/21/4/1289

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