Exploring the genetic basis of human population differences in DNA methylation and their causal impact on immune gene regulation

Exploring the genetic basis of human population differences in DNA methylation and their causal impact on immune gene regulation

Abstract Background DNA methylation is influenced by both environmental and genetic factors and is increasingly thought to affect variation in complex traits and diseases. Yet, the extent of ancestry-related differences in DNA methylation, their genetic determinants, and their respective causal impa...

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Bibliographic Details
Main Authors: Lucas T. Husquin, Maxime Rotival, Maud Fagny, Hélène Quach, Nora Zidane, Lisa M. McEwen, Julia L. MacIsaac, Michael S. Kobor, Hugues Aschard, Etienne Patin, Lluis Quintana-Murci
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Genome Biology
Subjects:
Epigenetics
DNA methylation
Ancestry
Gene expression
Mediation
Immunity
Online Access:http://link.springer.com/article/10.1186/s13059-018-1601-3

Internet

http://link.springer.com/article/10.1186/s13059-018-1601-3

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