Synaptic proteins promote calcium-triggered fast transition from point contact to full fusion

Synaptic proteins promote calcium-triggered fast transition from point contact to full fusion

The molecular underpinnings of synaptic vesicle fusion for fast neurotransmitter release are still unclear. Here, we used a single vesicle–vesicle system with reconstituted SNARE and synaptotagmin-1 proteoliposomes to decipher the temporal sequence of membrane states upon Ca2+-injection at 250–500 μ...

Full description

Bibliographic Details
Main Authors: Jiajie Diao, Patricia Grob, Daniel J Cipriano, Minjoung Kyoung, Yunxiang Zhang, Sachi Shah, Amie Nguyen, Mark Padolina, Ankita Srivastava, Marija Vrljic, Ankita Shah, Eva Nogales, Steven Chu, Axel T Brunger
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2012-12-01
Series:eLife
Subjects:
neurotransmitter release
synaptic vesicle fusion
SNARE
synaptotagmin
complexin
Online Access:https://elifesciences.org/articles/00109

Internet

https://elifesciences.org/articles/00109

Similar Items