Transcriptional Repressor HIC1 Contributes to Suppressive Function of Human Induced Regulatory T Cells

Transcriptional Repressor HIC1 Contributes to Suppressive Function of Human Induced Regulatory T Cells

Summary: Regulatory T (Treg) cells are critical in regulating the immune response. In vitro induced Treg (iTreg) cells have significant potential in clinical medicine. However, applying iTreg cells as therapeutics is complicated by the poor stability of human iTreg cells and their variable suppressi...

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Bibliographic Details
Main Authors: Ubaid Ullah, Syed Bilal Ahmad Andrabi, Subhash Kumar Tripathi, Obaiah Dirasantha, Kartiek Kanduri, Sini Rautio, Catharina C. Gross, Sari Lehtimäki, Kanchan Bala, Johanna Tuomisto, Urvashi Bhatia, Deepankar Chakroborty, Laura L. Elo, Harri Lähdesmäki, Heinz Wiendl, Omid Rasool, Riitta Lahesmaa
Format: Article
Language:English
Published: Elsevier 2018-02-01
Series:Cell Reports
Subjects:
iTreg
suppression
HIC1
FOXP3
regulatory SNP
RNA-seq
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718301190

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http://www.sciencedirect.com/science/article/pii/S2211124718301190

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