Calcineurin inhibitors suppress cytokine production from memory T cells and differentiation of naïve T cells into cytokine-producing mature T cells.

Calcineurin inhibitors suppress cytokine production from memory T cells and differentiation of naïve T cells into cytokine-producing mature T cells.

T cells have been classified as belonging to the Th1 or Th2 subsets according to the production of defining cytokines such as IFN-γ and IL-4. The discovery of the Th17 lineage and regulatory T cells shifted the simple concept of the Th1/Th2 balance into a 4-way mechanistic pathway of local and syste...

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Bibliographic Details
Main Authors: Kenshiro Tsuda, Keiichi Yamanaka, Hiroshi Kitagawa, Tomoko Akeda, Masanao Naka, Kaori Niwa, Takehisa Nakanishi, Masato Kakeda, Esteban C Gabazza, Hitoshi Mizutani
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3281079?pdf=render

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http://europepmc.org/articles/PMC3281079?pdf=render

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