Inflammatory Cytokines and SIRT1 Levels in Subcutaneous Abdominal Fat: Relationship With Cardiac Performance in Overweight Pre-diabetics Patients

Inflammatory Cytokines and SIRT1 Levels in Subcutaneous Abdominal Fat: Relationship With Cardiac Performance in Overweight Pre-diabetics Patients

Objectives: In obese patients the superficial adipose tissue expresses cytokines, and sirtuins, that may affect myocardial function. In this study, we investigated the effect of metformin therapy added to a hypocaloric diet on the inflammatory pattern and cardiac performance (MPI) in obese patients...

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Bibliographic Details
Main Authors: Celestino Sardu, Gorizio Pieretti, Nunzia D'Onofrio, Feliciano Ciccarelli, Pasquale Paolisso, Maria B. Passavanti, Raffaele Marfella, Michele Cioffi, Pasquale Mone, Anna M. Dalise, Franca Ferraraccio, Iacopo Panarese, Antonio Gambardella, Nicola Passariello, Maria R. Rizzo, Maria L. Balestrieri, Gianfranco Nicoletti, Michelangela Barbieri
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Physiology
Subjects:
pre-diabetes
obesity
visceral fat
sirtuin 1
cardiac performance
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01030/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2018.01030/full

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