Association of gliadin antibodies, HLA alleles, and schizophrenia in Cuban population patients
Introduction: Several lines of evidence have suggested an interesting link between gluten ingestion and schizophrenia. For example, increased levels of gliadin and transglutaminase antibodies have been observed in patients with schizophrenia. Methods: To verify these observations we compared t...
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doaj-74457d8ae33e4cdf99980a5b043440752020-11-25T01:38:54ZengUniversidad Católica de OrienteBionatura1390-93471390-93552016-05-0112626610.21931/RB/2016.01.02.4Association of gliadin antibodies, HLA alleles, and schizophrenia in Cuban population patientsJosé A. Galván0Hanlet Camacho1William W. Eaton2Marcelo Nazabal3María E. Fernández de Cossio4Isabel Guillen5Seidy Pedroso6Raúl Mendoza7Annia Ferrer8Juan Roca9Jesús Benitez10Lidia Inés Novoa11Department of Immunology. Institute of Hematology and Immunology. Havana, CubaInmunodiagnostics and Genomics Division, Center for Genetic Engineering and Biotechnology, Havana, Cuba.Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USAInmunodiagnostics and Genomics Division, Center for Genetic Engineering and Biotechnology, Havana, Cuba.Inmunodiagnostics and Genomics Division, Center for Genetic Engineering and Biotechnology, Havana, Cuba.Inmunodiagnostics and Genomics Division, Center for Genetic Engineering and Biotechnology, Havana, Cuba.Inmunodiagnostics and Genomics Division, Center for Genetic Engineering and Biotechnology, Havana, Cuba.Neuroscience Center. Havana, Cuba.Inmunodiagnostics and Genomics Division, Center for Genetic Engineering and Biotechnology, Havana, Cuba.Inmunodiagnostics and Genomics Division, Center for Genetic Engineering and Biotechnology, Havana, Cuba.Inmunodiagnostics and Genomics Division, Center for Genetic Engineering and Biotechnology, Havana, Cuba.Inmunodiagnostics and Genomics Division, Center for Genetic Engineering and Biotechnology, Havana, Cuba.Introduction: Several lines of evidence have suggested an interesting link between gluten ingestion and schizophrenia. For example, increased levels of gliadin and transglutaminase antibodies have been observed in patients with schizophrenia. Methods: To verify these observations we compared the prevalence of gliadin and transglutaminse antibodies, as well as the presence of the HLA alleles, HLA DQA1*0501-DQB1*02 (DQ2) and HLA-DQA1*0301-DQB1*0302 (DQ8), among patients with schizophrenia and healthy controls. A total of 108 patients with schizophrenia and 60 healthy controls were evaluated. Gliadin antibodies were determined by a visual semiquantitative assay and tissue transglutaminase antibodies were determined both by one-step immunochromatografic assay and ELISA. HLA typing was performed by PCR amplification using sequence-specific primers for each allele. Results: We found a strong association between the presence of gliadin antibodies and schizophrenia (OR 3.488; 95% CI, 1.43-8.44). However, tissue transglutaminase antibodies were not detected in either group neither by immunochromatograpic or ELISA. No significant association was found for the DQ2 or DQ8 heterodimer and the disease, but a significant positive association between schizophrenia and HLA alleles DQA1*0301 and DQB1*02 was present (OR = 2.80; 95% CI, 1.27-6.17, and OR = 2.37, 95% CI, 1.24-4.53, respectively). Conclusions: The present study showed that the presence of gliadin antibodies was not correlated with the presence of HLA DQA1*0301 or DQB1*02 alleles within the group of patients with schizophrenia. Our study replicates the findings that anti-gliadin antibodies are associated with schizophrenia but also suggests that the presence of these antibodies and the HLA alleles DQB1*02 and DQA1*0301 are independently associated with susceptibility to schizophrenia.http://revistabionatura.com/hla-alleles-and-schizophrenia-.htmlCeliac diseasegliadin antibodiestissue transglutaminase antibodiesHLAschizophreniaCuba. |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
José A. Galván Hanlet Camacho William W. Eaton Marcelo Nazabal María E. Fernández de Cossio Isabel Guillen Seidy Pedroso Raúl Mendoza Annia Ferrer Juan Roca Jesús Benitez Lidia Inés Novoa |
spellingShingle |
José A. Galván Hanlet Camacho William W. Eaton Marcelo Nazabal María E. Fernández de Cossio Isabel Guillen Seidy Pedroso Raúl Mendoza Annia Ferrer Juan Roca Jesús Benitez Lidia Inés Novoa Association of gliadin antibodies, HLA alleles, and schizophrenia in Cuban population patients Bionatura Celiac disease gliadin antibodies tissue transglutaminase antibodies HLA schizophrenia Cuba. |
author_facet |
José A. Galván Hanlet Camacho William W. Eaton Marcelo Nazabal María E. Fernández de Cossio Isabel Guillen Seidy Pedroso Raúl Mendoza Annia Ferrer Juan Roca Jesús Benitez Lidia Inés Novoa |
author_sort |
José A. Galván |
title |
Association of gliadin antibodies, HLA alleles, and schizophrenia in Cuban population patients |
title_short |
Association of gliadin antibodies, HLA alleles, and schizophrenia in Cuban population patients |
title_full |
Association of gliadin antibodies, HLA alleles, and schizophrenia in Cuban population patients |
title_fullStr |
Association of gliadin antibodies, HLA alleles, and schizophrenia in Cuban population patients |
title_full_unstemmed |
Association of gliadin antibodies, HLA alleles, and schizophrenia in Cuban population patients |
title_sort |
association of gliadin antibodies, hla alleles, and schizophrenia in cuban population patients |
publisher |
Universidad Católica de Oriente |
series |
Bionatura |
issn |
1390-9347 1390-9355 |
publishDate |
2016-05-01 |
description |
Introduction: Several lines of evidence have suggested an interesting link between gluten ingestion and schizophrenia. For example, increased levels of gliadin and transglutaminase antibodies have been observed in patients with schizophrenia.
Methods: To verify these observations we compared the prevalence of gliadin and transglutaminse antibodies, as well as the presence of the HLA alleles, HLA DQA1*0501-DQB1*02 (DQ2) and HLA-DQA1*0301-DQB1*0302 (DQ8), among patients with schizophrenia and healthy controls. A total of 108 patients with schizophrenia and 60 healthy controls were evaluated. Gliadin antibodies were determined by a visual semiquantitative assay and tissue transglutaminase antibodies were determined both by one-step immunochromatografic assay and ELISA. HLA typing was performed by PCR amplification using sequence-specific primers for each allele.
Results: We found a strong association between the presence of gliadin antibodies and schizophrenia (OR 3.488; 95% CI, 1.43-8.44). However, tissue transglutaminase antibodies were not detected in either group neither by immunochromatograpic or ELISA. No significant association was found for the DQ2 or DQ8 heterodimer and the disease, but a significant positive association between schizophrenia and HLA alleles DQA1*0301 and DQB1*02 was present (OR = 2.80; 95% CI, 1.27-6.17, and OR = 2.37, 95% CI, 1.24-4.53, respectively).
Conclusions: The present study showed that the presence of gliadin antibodies was not correlated with the presence of HLA DQA1*0301 or DQB1*02 alleles within the group of patients with schizophrenia. Our study replicates the findings that anti-gliadin antibodies are associated with schizophrenia but also suggests that the presence of these antibodies and the HLA alleles DQB1*02 and DQA1*0301 are independently associated with susceptibility to schizophrenia. |
topic |
Celiac disease gliadin antibodies tissue transglutaminase antibodies HLA schizophrenia Cuba. |
url |
http://revistabionatura.com/hla-alleles-and-schizophrenia-.html |
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