Modulation of lipid metabolism with the overexpression of NPC1L1 in mouse liver

Modulation of lipid metabolism with the overexpression of NPC1L1 in mouse liver

Niemann-Pick C1-like 1 protein (NPC1L1), a transporter crucial in intestinal cholesterol absorption, is expressed in human liver but not in murine liver. To elucidate the role of hepatic NPC1L1 on lipid metabolism, we overexpressed NPC1L1 in murine liver utilizing adenovirus-mediated gene transfer....

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Bibliographic Details
Main Authors: Makoto Kurano, Masumi Hara, Koichi Tsuneyama, Koji Okamoto, Naoyuki Iso-O, Teruhiko Matsushima, Kazuhiko Koike, Kazuhisa Tsukamoto
Format: Article
Language:English
Published: Elsevier 2012-11-01
Series:Journal of Lipid Research
Subjects:
biliary cholesterol
apoE-rich lipoprotein
ezetimibe
Niemann-Pick C1-like 1 protein
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520412453

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http://www.sciencedirect.com/science/article/pii/S0022227520412453

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