Taurine Antagonizes Macrophages M1 Polarization by Mitophagy-Glycolysis Switch Blockage via Dragging SAM-PP2Ac Transmethylation

Taurine Antagonizes Macrophages M1 Polarization by Mitophagy-Glycolysis Switch Blockage via Dragging SAM-PP2Ac Transmethylation

The excessive M1 polarization of macrophages drives the occurrence and development of inflammatory diseases. The reprogramming of macrophages from M1 to M2 can be achieved by targeting metabolic events. Taurine promotes for the balance of energy metabolism and the repair of inflammatory injury, prev...

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Bibliographic Details
Main Authors: Ling Meng, Cailing Lu, Bin Wu, Chunhua Lan, Laiming Mo, Chengying Chen, Xinhang Wang, Ning Zhang, Li Lan, Qihui Wang, Xia Zeng, Xiyi Li, Shen Tang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
M1 macrophage
low-grade inflammation
taurine
PP2Ac methylation
SAM
mitophagy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.648913/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.648913/full

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